纳米HAP/CPP/PLLA骨组织工程支架复合材料降解特性

现有支架材料的降解速率与骨细胞生长、繁殖速率不匹配,在降解过程中支架材料的强度、刚度衰减速率与成骨速率不匹配,支架材料在体内降解的酸性副产物会引起炎症反应.为克服以上困难,采用溶媒浇铸、颗粒滤取与气体发泡相结合的方法制备出纳米HAP/CPP/PLLA骨组织工程支架复合材料;选用生理盐水作为模拟体液进行降解实验,测试该支架复合材料的降解性能,用扫描电子显微镜对其在不同降解时期的微观结构进行观察.结果表明:纳米HAP/CPP/PLLA支架复合材料在降解过程中具有三维、连通、微孔网状结构,并具有良好的降解性能和生物相容性,是比较理想的骨组织工程支架材料.

Degradation characteristics of HAP/CPP/PLLA nanometer composite for scaffold of osteo-tissue engineering

The degradation rate of scaffold material available does not match the growth and reproduction rate of osteo-cell,the attenuation rate of strength and stiffness of scaffold material does not match the bone generation rate in its degradation process,and the acidic by-product of degradation of the scaffold material in human body may cause inflammation reaction.In order to overcome above-mentioned difficulties,a HAP/CPP/PLLA manometer composite for scaffold of osteo-tissue engineering was fabricated with the technique of solvent-casting and particle-leaching combined with the method of gaseous foaming.Degradation experiment was carried out with the physiological saline as simulative body fluids to test the degradation performance of this scaffold composite.Its microscopic structure in different degradation phases was observed with electronic scanner.The experimental result showed that this composite possessed three-dimensional,connective,and micro-porous networked structure,exhibiting good degradation performance and bio-compatibility,and being an ideal scaffold material for osteo-tissue engineering.