Die Abhängigkeit der Ca++-Aufnahme isolierter Mitochondrien des Herzmuskels von der Na+-und K+-Konzentration als mögliche Ursache der inotropen Digitaliswirkung |
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Authors: | H Dransfeld K Greeff D Hess A Schorn |
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Institution: | (1) Pharmakologisches Institut der Universität, 4 Düsseldorf, Deutschland |
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Abstract: | Summary In isolated mitochondria of heart muscle from rabbits and oxen there is, under suitable conditions, an accumulation of Ca++, which is significantly enhanced by elevating the K+/Na+ quotient of the incubation medium. K-strophanthine (10–5–10–7) does not influence the accumulation of Ca++ by the mitochondria of heart muscle. Therefore the intracellular increase in exchangeable Ca++ observed after digitalis-glycosides could be explained by a decrease of the intracellular K+/Na+ quotient, which is caused by inhibition of the membrane ATPase and diminishes the capacity for Ca++ accumulation in mitochondria. |
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