Guanylate cyclase in human platelets with different aggregability |
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| Authors: | Yu. Yu. Chirkov I. A. Tyshchuk I. S. Severina |
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| Affiliation: | (1) Institute of Biological and Medical Chemistry, USSR Academy of Medical Sciences, Pogodinskaya 10, 119832 Moscow, (USSR) |
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| Abstract: | Summary The activity of human platelet guanylate cyclase, and the activation of the enzyme by sodium nitroprusside were decreased in platelets with increased aggregability; these platelets were obtained from diabetes mellitus patients. Anomalies in guanylate cyclase activity and ADP-induced aggregation were more pronounced in platelets from subjects with type II than those with type I diabetes. |
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| Keywords: | Guanylate cyclase human platelets platelet aggregation diabetes mellitus |
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