| 神经电活动稳态调控抑制性突触传递的分子机制 |
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| 引用本文： | 彭懿蓉,于翔. 神经电活动稳态调控抑制性突触传递的分子机制[J]. 中国基础科学, 2011, 13(3): 26-29. DOI: 10.3969/j.issn.1009-2412.2011.03.003 |
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| 作者姓名： | 彭懿蓉 于翔 |
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| 作者单位： | 中国科学院上海生命科学研究院神经科学研究所神经科学国家重点实验室,上海,200031 |
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| 基金项目： | 国家973计划项目(2006CB806600、2006CB943903); 国家自然科学基金(30721004); 中国科学院(百人计划、KSCX2-YW-R-103) |
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| 摘 要： | 发育中的神经网络需要兼顾生长与稳定这两种相辅相成的需求.稳态可塑性可通过调节兴奋性或抑制性突触传递从而维持神经网络的稳定.已报道的关于稳态可塑性机制方面的研究主要集中在其对兴奋性突触传递的影响,很少关注其对抑制性突触的调控.运用体外培养的原代海马神经元,本项研究发现了持续增强神经元电活动4小时能够诱导抑制性突触传递的稳...
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| 关 键 词： | 稳态可塑性 神经网络电活动 抑制性突触 兴奋性突触 脑源性神经营养因子 |
Molecular Mechanisms Underlying Activity-induced Homeostatic Regulation of Inhibitory Synaptic Transmission |
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| Peng Yirong,Yu Xiang. Molecular Mechanisms Underlying Activity-induced Homeostatic Regulation of Inhibitory Synaptic Transmission[J]. China Basic Science, 2011, 13(3): 26-29. DOI: 10.3969/j.issn.1009-2412.2011.03.003 |
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| Authors: | Peng Yirong Yu Xiang |
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| Affiliation: | Peng Yirong,Yu Xiang Institute of Neuroscience and State Key Laboratory of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031 |
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| Abstract: | Developing neural circuits face the dual challenge of growing in an activity-induced fashion and maintaining stability through homeostatic mechanisms.Compared to our understanding of homeostatic regulation of excitatory synapses,relatively little is known about the mechanism mediating homeostatic plasticity of inhibitory synapses,especially that following activity elevation.Here,we found that elevating neuronal activity in cultured hippocampal neurons for 4h significantly increased the frequency and amplitu... |
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| Keywords: | homeostatic plasticity neural activity inhibitory synapses excitatory synapses BDNF |
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