基质金属蛋白酶在肿瘤细胞侵袭和迁移中的作用

基质金属蛋白酶是一类锌离子依赖的、能够降解细胞外基质的内肽酶，它通过降解细胞外基质促进肿瘤细胞的侵袭和转移；现就基质金属蛋白酶在肿瘤细胞侵袭和转移过程中的作用以及基质金属蛋白酶与临床恶性肿瘤的相关性进行简单综述。

Effects ofmatrixmetalloproteinase on the invasion and metastasis of antitumor

Abstract: Matrix metallop roteinases (MMPs) are zinc2dependent endopep tidases, which are capable of de2grading all kinds of extracellular matrix p roteins. For their p ivotal roles on the tumor invasion and metastasis,MMPs are becoming the key point for the research of antitumor compounds. Here, we try to summarize the develop2ment about the role ofMMPs in the tumor invasion and metastasis.