| 一种遗传算法的细胞跨膜信号传递调控模型 |
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| 引用本文： | 吴鸿修,仇建斌,陈良怡,娄雪林. 一种遗传算法的细胞跨膜信号传递调控模型[J]. 华中科技大学学报(自然科学版), 1999, 0(9) |
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| 作者姓名： | 吴鸿修 仇建斌 陈良怡 娄雪林 |
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| 作者单位： | 华中理工大学生物物理与生物化学研究所 |
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| 摘 要： | 分析了跨膜信号传导稳态模型以及电生理实验数据的局限性，针对生理情况下随机刺激和响应的特点，采用遗传算法优化模型动力学参数．结果与大量实验数据能较好地符合
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| 关 键 词： | 基因算法 跨膜信号传导 模型 |
A Study of the Model of Cellular Transmembrane Signal Tranduction Based on Genetic Algorithms |
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| Wu Hongxiu Qiu Jianbin Chen Liangyi Lou Xuelin. A Study of the Model of Cellular Transmembrane Signal Tranduction Based on Genetic Algorithms[J]. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY.NATURE SCIENCE, 1999, 0(9) |
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| Authors: | Wu Hongxiu Qiu Jianbin Chen Liangyi Lou Xuelin |
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| Affiliation: | Wu Hongxiu Qiu Jianbin Chen Liangyi Lou Xuelin |
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| Abstract: | The limitations of static transmembrane signal transduction model and the data from electrophysiology experiments are analyzed. We use genetic algorithms to optimize the kinetics parameters of the model according to the characteristic of random stimulus and response under physiological circumstance. The results conform to the mass experiment data obtained. The genetic algorithms embody some common characteristics and the particularities of cellular transmembrane signal transduction in the process of optimization. |
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| Keywords: | genetic algorithms transmembrane signal transduction model Wu Hongxiu Prof. Institute of Biophysics & Biochemistry HUST Wuhan 430074 China. |
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