Population choice in mapping genes for complex diseases |
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Authors: | Wright A F Carothers A D Pirastu M |
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Institution: | MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK. alan.wright@hgu.mrc.ac.uk |
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Abstract: | The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a critical factor when designing a study, and that genetically simplified isolates are more useful than diverse continental populations under most assumptions. |
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