静脉药瘾者血源传播病毒感染情况的调查分析

目的:调查静脉药瘾者主要血源传播病毒HBV、HCV、HGV、CMV和HSV的感染率。方法:采用酶联免疫吸附法、放射免疫法R、T-PCR和荧光定量PCR法,检测了406例静脉药瘾者血清,其中共用注射器者49.01%,同时设立102例正常健康体检者作为对照。结果:静脉药瘾者HBV、HCV、HGV、CMV和HSV的感染率分别是36.45%、69.7%、1.97%、2.71%和3.45%,其中总感染人数321人(79.06%)和重叠感染人数128人(31.53%),尤其有共用注射器者感染率及重叠感染率均高于未共用者,两者差异具有显著性意义(P<0.05)。对照组检测仅发现存在HBV感染(17.6%),其余病毒感染指标均为阴性。结论:静脉药瘾者血源传播病毒感染率明显增高,其中以HCV感染最为突出,并且共用注射器是导致感染扩大的危险要素。

Analysis on the Infection Rates of Blood Transmission Virus in Intravenous Drug Users

Objective: In order to assess the infection condition of HBV?HCV?HGV?HSV and CMV in Intravenous Drug Users(IVDUs).Methods: It is detected that anti-HBV?HCV?HGV?HSV?CMV markers by ELISA in 406 sera and 102 normal controls.While we detected HCV RNA by RT-PCR and Fluorescence Quantitative PCR methods.Results: The results showed that anti-HGV?HSV and CMV positive is 1.97%?2.71% and 3.45% respctively,total HBV infection rate is 36.45%,HBsAg carrier 5.91%,HBeAg positive 3.96% in IVDUs.HBV infection rate is 17.65%,HBsAg carrier 0.98%,HBeAg positive 1.96% in the controls.Others are negative.The infection rates and coinfection rates are very prominent in the injector co-users of IVDUs(49.01%).Conclusion: It indicates that IVDUs is high risk population of blood transmission virus infection,especially HCV infection.