Covalent binding of aflatoxin B1 to liver DNA in rats pretreated with ethanol |
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Authors: | M. Marinovich W. K. Lutz |
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Affiliation: | (1) Institute of Toxicology, Swiss Federal Institute of Technology and University of Zurich, CH-8603 Schwerzenbach, (Switzerland);(2) Present address: Institute of Pharmacology and Pharmacognosy, University of Milan, I-20129 Milan, Italy |
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Abstract: | Summary Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen [3H]aflatoxin B1 (AFB1). 24 h later, the level of DNA-bound AFB1 was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to be due to an effect on the metabolic activation and inactivation processes governing the formation of DNA-binding AFB1 metabolites.To whom correspondence should be addressed.Acknowledgment. We thank the European Science Foundation for the Toxicology Research Fellowship awarded to M.M. |
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Keywords: | Carcinogenesis DNA covalent binding aflatoxin ethanol |
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