Accelerated development of a Th-2 type factor in animals with and without an imbalance between help and suppression |
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| Authors: | T Matsuzawa B Cinader |
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| Institution: | (1) Departments of Clinical Biochemistry, Medical Biochemistry, Medical Genetics, University of Toronto, Medical Sciences Building, M5S 1A8 Toronto, Ontario, Canada;(2) Institute of Immunology, University of Toronto, Medical Sciences Building, M5S 1A8 Toronto, Ontario, Canada;(3) Present address: Sakura National Hospital, 285 Sakura-shi, Chiba Prefecture, Japan |
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| Abstract: | Summary A helper factor can be detected in antigen-treated supernatants from spleen T and adherent cells of sensitized animals. This factor promotes an indirect hapten-specific plaque forming response of B cells, irrespective of the identity of the carrier, i.e. provides the Th-2 type of help. Factor production increases with age and occurs most rapidly in strains known to have an accelerated decrease of suppressor capacity. The reason for the inverse correlation between suppressor capacity and the Th-2 type of helper factor is discussed.Acknowledgments. Thanks are due to the Medical Research Council, the National Cancer Institute of Canada and the National Health Research and Development Program for financial support; T.M. is indebted to the Medical Research Council for personal support. |
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