Inducement of blood vessel formation by ovarian extracts from mice injected with gonadotropins |
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| Authors: | E Sato T Ishibashi S S Koide |
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| Institution: | (1) Department of Animal Science, College of Agriculture, Kyoto University, 606 Kyoto, (Japan);(2) Center for Biomedical Research, The Population Council, 1230 York Avenue, 10021 New York, New York, USA |
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| Abstract: | Summary Ovarian extracts prepared from immature mice injected with human chorionic gonadotropin (hCG) and pregnant mare serum gonadotropin (PMSG) were assayed for angiogenic activity. The assay method consisted of implanting a film coated with ovarian extracts to the lateral wall of the m.rectus abdominus of a mouse for 20 days and examining the site for vascularization. The higher angiogenic activity obtained with PMSG-treated extract may be related to its follicle stimulating activity.Acknowledgment. Part of this work was supported by a grant from The Ministry of Education, Japan (No. 576165). |
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