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Insulin secretion and (pro)insulin biosynthesis of cultured mice islets after glibenclamide loading in vitro |
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| Authors: | B Ziegler B Wilke M Ziegler S Schmidt H Zühlke |
| Abstract: | Isolated islets from C57Bl/6J mice exposed to 10 mmoles/l glucose supplemented with 5 micrograms/ml glibenclamide for 48 h released significantly less insulin in the subsequent short-time incubation than untreated controls (without glibenclamide), whereas insulin biosynthesis was not suppressed by glibenclamide treatment. |
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