Identification of foreign gene sequences by transcript filtering against the human genome. |
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| Authors: | Griffin Weber Jay Shendure David M Tanenbaum George M Church Matthew Meyerson |
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| Affiliation: | Department of Adult Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. |
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| Abstract: | We have developed a computational subtraction approach to detect microbial causes for putative infectious diseases by filtering a set of human tissue-derived sequences against the human genome. We demonstrate the potential of this method by identifying sequences from known pathogens in established expressed-sequence tag libraries. |
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