Optically active alcohols: Resolution and synthesis from asymmetric reduction of prochiral ketones |
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Authors: | Hu Xian-ming Liu Jun |
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Institution: | (1) College of Chemistry, Wuhan University, 430072 Wuhan, China |
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Abstract: | The recent methods of resolution, enantiomeric excess determination and synthesis of optically active alcohols from asymmetric
reduction of prochiral ketones are reviewed in the article with references. Important functions and applications of optically
active alcohols in biological and chemical research area are described in an introduction part. The following part deals with
resolution and enaniiomeric excess determination of racemic alcohols. The next part discusses asymmetric reduction of prochiral
ketone and related compounds, which including: (a) Reduction by chirally modified aluminum and boron hydrides: (b) Catalytic
reduction with chiral transition metal, complexes: (c) Enantioselective reduction by hydride transfer from carbon: (d) Biocatalytic
reduction: (e) Asymmetric synthesis of chiral nonracemic alcohols with help of physical methods. A conclusion about optically
active, alcohols from asymmetric reduction of ketones followes in the final part of article.
Foundation item: Supported by the Fundation of High Education Ministry for the Scholars Back from Abroad
Biography: HU Xian-ming (1950-), male, Associate Professor, Ph. D. (Univ of Groningen), email: xmhu@wh.edu.cn. |
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Keywords: | optically active alcohols resolution asymmetric reduction review |
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