Inhibition of brain enolases by acrylamide and its related compounds in vitro,and the structure-activity relationship |
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| Authors: | H. Tanii K. Hashimoto |
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| Affiliation: | (1) Department of Hygiene, School of Medicine, Kanazawa University, 13-1, Takara-machi, 920 Kanazawa, (Japan) |
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| Abstract: | Summary Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones. |
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| Keywords: | Rat brain Enolase acrylamide acrylamide derivatives neurotoxicity structure-activity relationship |
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