Role of serotonin in the hepato-gastroIntestinal tract: an old molecule for new perspectives |
| |
Authors: | M Lesurtel C Soll R Graf P-A Clavien |
| |
Institution: | 1. Swiss HPB Center, Department of Visceral and Transplant Surgery, University Hospital of Zurich, R?mistrasse 100, CH-8091, Zürich, Switzerland 2. Department of HPB Surgery, Beaujon Hospital, Paris University VII, Clichy, France
|
| |
Abstract: | Beside its role as a neurotransmitter in the central nervous system, serotonin appears to be a central physiologic mediator
of many gastrointestinal (GI) functions and a mediator of the brain-gut connection. By acting directly and via modulation
of the enteric nervous system, serotonin has numerous effects on the GI tract. The main gut disturbances in which serotonin
is involved are acute chemotherapy-induced nausea and vomiting, carcinoid syndrome and irritable bowel syndrome. Serotonin
also has mitogenic properties. Platelet-derived serotonin is involved in liver regeneration after partial hepatectomy. In
diseased liver, serotonin may play a crucial role in the progression of hepatic fibrosis and the pathogenesis of steatohepatitis.
Better understanding of the role of the serotonin receptor subtypes and serotonin mechanisms of action in the liver and gut
may open new therapeutic strategies in hepato-gastrointestinal diseases.
Received 15 August 2007; received after revision 1 November 2007; accepted 5 November 2007 |
| |
Keywords: | Serotonin platelet gut liver regeneration gastrointestinal dysfunction |
本文献已被 PubMed SpringerLink 等数据库收录! |
|