| 不同持续时间低氧后训练对大鼠骨骼肌组织细胞凋亡的影响 |
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| 引用本文： | 刘铭,张沙骆,汤长发,瞿树林. 不同持续时间低氧后训练对大鼠骨骼肌组织细胞凋亡的影响[J]. 湖南师范大学自然科学学报, 2009, 32(2) |
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| 作者姓名： | 刘铭 张沙骆 汤长发 瞿树林 |
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| 作者单位： | 1. 湖南师范大学体育学院,中国,长沙,410012
2. 长沙民政职业技术学院,中国,长沙,410004 |
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| 摘 要： | 探讨低氧训练对骨骼肌细胞凋亡的影响,为科学地指导运动员进行低氧训练提供实验依据.选雄性SD大鼠60只,随机分为6组,正常对照组(A组),低氧8 h组(B组),低氧12 h组(C组),训练对照组(D组),低氧8 h训练组(E组),低氧12 h训练组(F组).采用零坡度跑台训练方式,对D、E和F3组以25 m/min的速度在常氧环境中每天训练1 h.于次日早上8点,将B、C、E和F组放人低氧舱内,氧浓度为12.5%(相当于4 km海拔高度),过8 h和12 h后(当日16点和20点),分别将B、E组和C、F组取出放人正常氧浓度环境.训练共持续4周,每周5 d.最后一次训练后24 h处死,取大鼠比目鱼肌组织,用免疫组织化学法测定Bax和Bcl-2蛋白表达的阳性细胞个数,用TUNEL法测定凋亡指数.结果表明,随着低氧时间的延长,低氧训练使大鼠骨骼肌组织的细胞凋亡有减少的趋势,从而起到保护作用.结论:低氧训练能使骨骼肌组织损害减小.
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| 关 键 词： | 低氧训练 骨骼肌 细胞凋亡 |
The Expression of Different Hypoxic Training Time in Skeletal Muscle Apoptosis of Rats |
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| LIU Ming,ZHANG Sha-luo,TANG Chang-fa,QU Shu-lin. The Expression of Different Hypoxic Training Time in Skeletal Muscle Apoptosis of Rats[J]. Journal of Natural Science of Hunan Normal University, 2009, 32(2) |
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| Authors: | LIU Ming ZHANG Sha-luo TANG Chang-fa QU Shu-lin |
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| Affiliation: | 1.Institute of Physical Education;Hunan Normal University;Changsha 410012;China;2.Changsha Social Work College;Changsha 410004;China |
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| Abstract: | Object:to examine the effect of hypoxic exercise to rat's oxygen transportation ability and skeletal muscle tissue apoptosis, which could provide an experimental records to scientific guidance of exercisers' hypoxic exercise. Method: take 60 male SD rats, which are randomly distributed to 6 groups, 10 rats each, which are normal contrast group (Group A), hypoxia 8-hour group (Group B), hypoxia 12-hour group (Group C), training contrast group (Group D), hypoxia 8-hour training group (Group E), hypoxia 12-hou... |
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| Keywords: | Bax Bcl-2 |
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