Pharmacologic therapeutic window of pramiracetam demonstrated in behavior,EEG, and single neuron firing rates |
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| Authors: | B. P. H. Poschel P. M. Ho F. W. Ninteman M. J. Callahan |
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| Affiliation: | (1) Department of Pharmacology, Warner-Lambert/Parke-Davis Pharmaceutical Research, 48105 Ann Arbor, Michigan, USA |
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| Abstract: | Summary Following oral or intravenous administration, a representative cognition activator drug, pramiracetam sulfate, is shown to have a pharmacologic therapeutic window at three different levels of study: learned behavior, gross EEG activity of the frontal cortex and hippocampus, and firing rate of single hippocampal neurons. |
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| Keywords: | Pramiracetam sulfate cognition activator nootropic therapeutic window learning quantitative EEG single CA-1 neuron firing |
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