| 孕烯醇酮和孕烯醇酮硫酸盐对小鼠不同脑区^3H—GABA与GABAB受体结合的影响 |
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| 引用本文： | 周雪瑞.孕烯醇酮和孕烯醇酮硫酸盐对小鼠不同脑区^3H—GABA与GABAB受体结合的影响[J].四川师范大学学报(自然科学版),2001,24(2):182-184. |
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| 作者姓名： | 周雪瑞 |
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| 作者单位： | 淮阴师范学院 生物系, |
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| 摘 要： | 采用放射配体受体结合分析法，研究了孕烯醇酮（Pe）和孕烯醇酮（Pes)对小鼠不同脑区^3H-GABA与GABAB受体结合的影响。结果显示，Pe对小鼠下丘脑、大脑皮层、海马、小脑GABAB受体的结合均有抑制效应，且能被GABAB受体激动剂巴氯芬（Bac)所阻断并翻转。Pes对大脑皮层、海马、小脑GABAB受体的结合有抑制作用，而对下丘脑则有促进作用。Bac能阻断Pes的抑制作用（海马除外），加强Pes的促进作用。实验结果提示，Pe,Pes对各脑区GABAB受体的结合具有一定的影响作用，且多为抑制效应。
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| 关 键 词： | 孕烯醇酮 孕烯醇酮硫酸盐 GABAB受体 ^3H－GABA 甾体类镇静药物 抑制效应 小鼠脑区 |
| 文章编号： | 1001-8395（2001）02-0182-03 |
| 修稿时间： | 2000年8月20日 |
Effects of Pregnenolone
and Pregnenolone Sulfate on 3H-GABA Bound with GABAB Receptor in
Different Areas of Mice Brain |
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| ZHOU Xue-rui.Effects of Pregnenolone
and Pregnenolone Sulfate on 3H-GABA Bound with GABAB Receptor in
Different Areas of Mice Brain[J].Journal of Sichuan Normal University(Natural Science),2001,24(2):182-184. |
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| Authors: | ZHOU Xue-rui |
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| Abstract: | By using radioactive ligand-receptor binding assay, this paperreported the effects of pregnenolong (Pe) and pregnenolone sulfate (Pes) on 3H-GABA bound with GABAB receptor in different areas of mice brain. The result showed that Pe decreased the binding of 3H-GABA with GABAB receptor, and it could be blocked and turned over by baclofen. Pes markedly decreased the binding of 3H-GABA with GABAB receptor in cerebral cortex and hippocampus and increased the binding in hypothalamus of mice brain. Baclofen could blocked the inhibition effect, enhance the effects of increase. These results suggested that major effects of Pe and Pes on 3H-GABA bound with GABAB receptor in different areas of mice brain were inhibition effects. |
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