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模式生物斑马鱼在听觉领域的应用
引用本文:刘可春,高燕,张云,何秋霞,韩利文,李宁,季秀娜,孙晨.模式生物斑马鱼在听觉领域的应用[J].山东科学,2019,32(5):46-53.
作者姓名:刘可春  高燕  张云  何秋霞  韩利文  李宁  季秀娜  孙晨
作者单位:齐鲁工业大学(山东省科学院),山东省科学院生物研究所, 山东省人类疾病斑马鱼模型与药物筛选工程技术研究中心,山东 济南 250103
基金项目:山东省重点研发计划 (2017YYSP032);山东省科学院青年基金(2019QN005);山东省攀登计划(tspd20181211)
摘    要:耳聋疾病严重影响着患者的生存质量。选择合适的模式生物,对耳聋疾病进行研究,可为该疾病的治疗和药物研发等提供可靠数据。斑马鱼是近年来兴起研究的一种新型脊椎动物模式生物,具有独特的自身优势,其在听觉领域的应用正日益受到人们的关注。基于此,就斑马鱼在听觉领域的研究优势、应用进展以及常用的技术方法等进行了综述。

关 键 词:斑马鱼  听觉系统  研究优势  应用进展  技术方法  
收稿时间:2019-06-26

Zebrafish as a model organism for hearing research
LIU Ke-chun,GAO Yan,ZHANG Yun,HE Qiu-xia,HAN Li-wen,LI Ning,JI Xiu-na,SUN Chen.Zebrafish as a model organism for hearing research[J].Shandong Science,2019,32(5):46-53.
Authors:LIU Ke-chun  GAO Yan  ZHANG Yun  HE Qiu-xia  HAN Li-wen  LI Ning  JI Xiu-na  SUN Chen
Affiliation:Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences),Jinan 250103, China
Abstract:Hearing loss has a substantial effect on the quality of patients′ life. The study on hearing loss using appropriate model organisms can provide reliable data for disease treatment and drug development. Zebrafish has emerged as a new type of vertebrate model organism in recent years. Because of its unique advantages, there is a growing interest in the use of zebrafish in research related to human hearing disorders. Considering this scenario, the paper reviews the research advantages, application progress, and common techniques used in the field of hearing research involving zebrafish.
Keywords:zebrafish  auditory system  research advantage  application progress  technique  
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