From immune response to cancer: a spot on the low molecular weight protein tyrosine phosphatase |
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Authors: | A C S Souza S Azoubel K C S Queiroz M P Peppelenbosch C V Ferreira |
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Institution: | 1. Biochemistry Department, University of Campinas, UNICAMP, Campinas, SP, CEP: 13083–970, Brazil 2. Instituto de Biologia, Departamento de Bioquímica, Cidade Universitária Zeferino Vaz, Bar?o Geraldo, Campinas, SP, CEP: 13083–970, Brazil 3. Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
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Abstract: | Reversible tyrosine phosphorylation is a key posttranslational regulatory modification of proteins in all eukaryotic cells
in normal and pathological processes. Recently a pivotal janus-faced biological role of the low molecular weight protein tyrosine
phosphatase (LMWPTP) has become clear. On the one hand this enzyme is important in facilitating appropriate immune responses
towards infectious agents, on the other hand it mediates exaggerated inflammatory responses toward innocuous stimuli. The
evidence that LMWPTP plays a role in oncological processes has added a promising novel angle. In this review we shall focus
on the regulation of LMWPTP enzymatic activity of signaling pathways of different immunological cells, the relation between
genetic polymorphism of LMWPTP and predisposition to some type of inflammatory disorders and the contribution of this enzyme
to cancer cell onset, growth and migration. Therefore, the LMWPTP is an interesting target for pharmacological intervention,
thus modifying both inappropriate cellular immune responses and cancer cell aggressiveness.
Received 15 August 2008; received after revision 06 October 2008; accepted 14 October 2008 |
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Keywords: | " target="_blank"> Low molecular weight protein tyrosine phosphatase cancer immune system inflammation |
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