| 苯并[a]芘对罗非鱼肝脏抗氧化防御系统的影响 |
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| 引用本文： | 黄长江,胡晓蓉,董巧香.苯并[a]芘对罗非鱼肝脏抗氧化防御系统的影响[J].汕头大学学报(自然科学版),2006,21(4):51-56. |
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| 作者姓名： | 黄长江 胡晓蓉 董巧香 |
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| 作者单位： | 1. 温州医学院环境与公共卫生学院,浙江,温州,325053
2. 汕头大学海洋生物研究所,广东,汕头,515063 |
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| 基金项目： | 广东省科技攻关项目;温州医学院科研资助项目 |
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| 摘 要： | 研究罗非鱼暴露在苯并a]芘(Ba]P)后,其肝脏3种抗氧化酶——超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GPx)——活性的剂量时间效应.结果显示,SOD和CAT都表现出在暴露初期被迅速抑制,然后诱导,再被抑制的反应模式,并且CAT对污染的胁迫反应比SOD更加敏感,二者均是Ba]P污染的良好标志物.相比之下,GPx的胁迫反应不明显,长时间暴露在高剂量下才表现出诱导趋势,并不适合于短时间暴露下单独用来作为污染监测的生物标志物.
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| 关 键 词： | 苯并[a]芘 罗非鱼 抗氧化防御系统 超氧化物歧化酶 过氧化氢酶 谷胱甘肽过氧化物酶 |
| 文章编号： | 1001-4217（2006）04-0051-06 |
| 收稿时间： | 2006-06-01 |
| 修稿时间： | 2006年6月1日 |
Effects of Benzo[a]pyrene on Antioxidant Defense System in Tilapia Liver |
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| HUANG Chang-jiang,HU Xiao-rong,DONG Qiao-xiang.Effects of Benzo[a]pyrene on Antioxidant Defense System in Tilapia Liver[J].Journal of Shantou University(Natural Science Edition),2006,21(4):51-56. |
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| Authors: | HUANG Chang-jiang HU Xiao-rong DONG Qiao-xiang |
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| Institution: | 1. School of Envircmmental and Public ltcalth, Wenzhou Medical College, Wcnzhou 325053, Zhcjiang, China, 2. Marine Biology Institute of Shantou University, Shantou 515063, Guangdong, China |
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| Abstract: | The effect of Ba]P on antioxidant defense system in the liver of juvenile hybrid tilapia(Oreochromis niloticus X O.aureus)was evaluated in this study,including SOD,CAT,and GPx after exposing the fish to Ba]P of 7 doses for various time periods.The activities of both SOD and CAT decreased initially after a short period of exposure,and increased,but decreased at last.But CAT responded faster,and is more sensitive than SOD at lower dosage.Both SOD and CAT could be used as sensitive biomarkers for Ba]P toxicity studies.GPx activity varied among the test,and a distinct response to Ba]P treatment was delayed to day 7 in the highest concentration,thus it was not considered as a suitable biomarker for acute toxicity studies for Ba]P effects. |
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| Keywords: | Benzo[a]pyrene tilapia antioxidant defense system Superoxide dismutase(SOD) Catalase(CAT) Glutathione peroidase(GPx) |
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