Effect of various doses of catecholestrogens on uterine eosinophilia in the immature rat |
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| Authors: | P Baumann A N Tchernitchin G Grunert P Ball |
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| Institution: | (1) Clinical Endocrinology, Institute of Biochemical Endocrinology, Medical School, Ratzeburger Allee 160, D-2400 Lübeck, (Federal Republic of Germany);(2) Laboratory of Experimental Endocrinology, Department of Experimental Morphology, University of Chile Medical School, Casilla 21104, Correo 21, Santiago, (Chile) |
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| Abstract: | Summary This paper describes the induction of uterine eosinophilia as well as of deep endometrial edema and increase of uterine wet weight in the immature rat by the catecholestrogens 2-OH-estradiol and 4-OH-estradiol. These effects are thought to be mediated by eosinophils via a specific eosinophil receptor system. 4-OH-estradiol was equipotent with estradiol, whereas the effect of 2-OH-estradiol was significantly weaker.Acknowledgments. This work was supported by Grant B-1493-8435 from the University of Chile. We are indebted to Prof. R. Knuppen, Lübeck, for providing the CE. |
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| Keywords: | Catecholestrogens uterus estrogenic responses uterine eosinophilia |
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