| 超临界流体抗溶剂结晶流程设计与装置研制 |
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| 引用本文： | 黄德春,刘巍,乐龙,史益强,王志祥.超临界流体抗溶剂结晶流程设计与装置研制[J].南京理工大学学报(自然科学版),2010,34(1). |
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| 作者姓名： | 黄德春 刘巍 乐龙 史益强 王志祥 |
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| 作者单位： | 1. 中国药科大学,药学院,江苏,南京,210009
2. 南京师范大学,机电工程系,江苏,南京,210042 |
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| 基金项目： | 江苏省高技术研究资助项目(BG2005034) |
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| 摘 要： | 针对近年来逐渐兴起的超临界流体抗溶剂(SAS)结晶分离技术,为简化其操作流程及降低相应的装置建造成本,在汲取超临界萃取装置研制经验的基础上,通过对加压泵的结构改造,以及对净滤、管道和冷凝等子系统的合理配置,以超临界CO2为抗溶剂,设计并加工了一套适于生化及抗生素类物系处理的间歇流程与装置,其建造成本较大幅度地低于国际同类产品的市场报价。通过建毕后的水压试验,以及结合对柠檬酸-丙酮溶液的SAS制粒实验,结果发现:所建装置不仅加压过程平稳、快捷,系统密封可靠,且操控性能优良,实测产率随压强及温度的变化趋势亦均与文献报道相吻合,即产率随压强的增加而升高,随温度的增加而先升后降。
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| 关 键 词： | 超临界流体抗溶剂 结晶 流程设计 装置研制 |
Flow Design and Device Development of Supercritical Fluid Anti-solvent Crystallization |
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| HUANG De-chun,LIU Wei,YUE Long,SHI Yi-qiang,WANG Zhi-xiang.Flow Design and Device Development of Supercritical Fluid Anti-solvent Crystallization[J].Journal of Nanjing University of Science and Technology(Nature Science),2010,34(1). |
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| Authors: | HUANG De-chun LIU Wei YUE Long SHI Yi-qiang WANG Zhi-xiang |
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| Institution: | 1.School of Pharmacy/a>;China Pharmaceutical University/a>;Nanjing 210009/a>;China/a>;2.Department of Mechanical Electronics Engineering/a>;Nanjing Normal University/a>;Nanjing 210042/a>;China |
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| Abstract: | To simplify the operation flow and drop the device building cost of supercritical fluid anti-solvent(SAS) crystallization,one of the newly emerging separation technologies in recent years,based on the investigation of supercritical extraction device development,a batch flow employing the supercritical CO2 as an anti-solvent is designed for the biochemical and antibiotic material treatments.A set of small scale device is built by combining with the reconstruction of pressure pump and the rational collocation... |
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| Keywords: | supercritical fluid anti-solvent crystallization flow designs device development |
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