Monoamines in brain and urine of rats with hereditary hypothalamic diabetes insipidus |
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| Authors: | B E Leonard F Ramaekers H Rigter |
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| Institution: | (1) Pharmacology Department, Scientific Development Group, Organon International B.V., P.O. Box 20, Oss, (The Netherlands);(2) Present address: Pharmacology Department, University College, Galway, Republic of Ireland |
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| Abstract: | Summary Monoamine levels in brain and urine of homozygous and heterozygous diabetes insipidus (DI) rats (Brattleboro strain) were assessed. Homozygous DI rats had a higher whole brain content of serotonin than their heterozygous littermates. However, when corrected for differences in brain weight, homozygous DI also appeared to have higher brain concentrations of noradrenaline, tyrosine and GABA. The total 24 h excretion of all amines and their precursors was greater in the homozygous than in the heterozygous rats.The authors thankHerman Müller andIneke van de Veerdonk for their assistance with part of this study. |
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