| 超临界溶液快速膨胀法制灰黄霉素微粒的预膨胀 |
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| 引用本文： | 陈鸿雁,周永传,邓修,戴干策.超临界溶液快速膨胀法制灰黄霉素微粒的预膨胀[J].华东理工大学学报(自然科学版),2000,26(1):18-20. |
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| 作者姓名： | 陈鸿雁 周永传 邓修 戴干策 |
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| 作者单位： | 华东理工大学化学工程研究所,上海,200237 |
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| 摘 要： | 用均相成核理论分析了超临界ＣＯ２快速膨胀法制备灰黄霉素微细颗粒过程中的预膨胀操作。指出在类似于灰黄霉素这样在反常冷凝区进行的ＲＥＳＳ过程,预膨胀段的加热不会导致溶质灰黄霉素在预膨胀段提前析出。
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| 关 键 词： | 超临界 灰黄霉素 晶粒细化 溶液体速膨胀 |
| 修稿时间： | 1999-08-20 |
Preexpansion of Fine Griseofulvin Particle Formation by Rapid Expansion of Supercritical Solution |
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| CHEN Hong yan ,ZHOU Yong chuan,DENG Xiu,DAI Gan ce.Preexpansion of Fine Griseofulvin Particle Formation by Rapid Expansion of Supercritical Solution[J].Journal of East China University of Science and Technology,2000,26(1):18-20. |
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| Authors: | CHEN Hong yan ZHOU Yong chuan DENG Xiu DAI Gan ce |
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| Institution: | CHEN Hong yan *,ZHOU Yong chuan,DENG Xiu,DAI Gan ce |
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| Abstract: | The pre expansion operation of rapid expansion of supercritical solution (RESS) is investigated by classical homogeneous nucleation theory in this article. Griseofulvin will not deposit from the supercritical CO 2 even though the supersaturation increases with the increasing pre expansion temperature. Otherwise, the lower pre expansion pressure results in higher nucleation rate. Therefore, high pre expansion temperature can be chosen when higher pre expansion pressure is set. |
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| Keywords: | supercriticality homogeneous nucleation crystallization griseofulvinum grain refinement |
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