| 液相光气法合成L-赖氨酸乙酯二异氰酸酯工艺改进 |
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| 作者单位： | ;1.云南民族大学民族药资源化学国家民委-教育部重点实验室;2.中国科学院成都有机化学研究所 |
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| 摘 要： | L-赖氨酸乙酯二异氰酸酯是一类有着良好应用前景的医用高分子材料的关键中间体.采用固体光气作为光气前体物质,在活性炭作用下生成光气并导入氯苯,制得光气的氯苯溶液,再通过与L-赖氨酸乙酯二盐酸盐反应合成了L-赖氨酸乙酯二异氰酸酯.在优化的反应条件下,反应总收率为80%.与传统光气法相比,具有操作和计量方便,安全性好的优点.
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| 关 键 词： | L-赖氨酸 二异氰酸酯 光气 活性炭 |
Improved synthesis of L-lysine ethyl ester diisocyanate from phosgene in the liquid phase |
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| Institution: | ,Key Laboratory of Chemistry in Ethnic Medicinal Resources of State Ethnic Affairs Commission & Ministry of Education of China,Yunnan Minzu University,Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences |
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| Abstract: | L-lysine ethyl ester diisocyanate is a key intermediate of a kind of medical polymers which have potential application prospect.Using triphosgene as the precursor of phosgene,phosgene was released under the Catalysis of active carbon and then introduced into a flask containing chlorobenzene.Subsequently,the solution of L-lysine ethyl ester was added dropwise into the phosgene solution to generate the target product.Under the optimum reaction conditions,80% total yield was obtained.Compared with the traditional synthetic method of using gaseous phosgene,this protocol has the advantages of convenient measurement and operation,as well as good safety. |
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| Keywords: | L-lysine diisocyanate phosgene active carbon |
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