| 新藤黄酸纳米囊的肝靶向研究 |
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| 引用本文： | 侯甲福,刘世娟,于凤波,李文超,李雪梅,梁启超,王元奕.新藤黄酸纳米囊的肝靶向研究[J].实验室科学,2013(6):26-28,32. |
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| 作者姓名： | 侯甲福 刘世娟 于凤波 李文超 李雪梅 梁启超 王元奕 |
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| 作者单位： | [1]牡丹江医学院 [2]仁合堂药业有限责任公司,黑龙江牡丹江157011 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目（项目编号：12521580）;牡丹江医学院科学技术研究项目（项目编号：2011-25）;黑龙江省中医药科研项目（项目编号：ZHY12-W049）;黑龙江省中医药科研项目（项目编号：ZHY12-W050）. |
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| 摘 要： | 目的：研究新藤黄酸纳米囊（NGA-NC）在小鼠体内的肝靶向性.方法：HPLC法测定NGA-NC试验组与新藤黄酸（NGA）对照组小鼠心、肝、脾、肺、肾及血浆中NGA的含量,比较两组小鼠体内药物分布特点,进行靶向评价.结果：NGA-NC试验组与NGA对照组比较,在肝脏的分布差异有显著性,NGA-NC组能显著增加NGA在肝脏的分布.结论：NGA-NC能增加NGA的肝靶向性.
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| 关 键 词： | 新藤黄酸 纳米囊 高效液相色谱法 |
Study on liver targeting of neogambogic acid nanocapsules |
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| HOU Jia-fu,LIU Shi-juan,YU Feng-bo,LI Wen-chao,LI Xue- mei,HANG Qi-chao,WANG Yuan-yi.Study on liver targeting of neogambogic acid nanocapsules[J].Laboratory Science,2013(6):26-28,32. |
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| Authors: | HOU Jia-fu LIU Shi-juan YU Feng-bo LI Wen-chao LI Xue- mei HANG Qi-chao WANG Yuan-yi |
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| Institution: | 1. Mudanjiang Medical College, Mudanjiang 157011; 2. Renhetang Medicine Limited Liability Company, Mudanjiang 157011, China) |
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| Abstract: | Objective： To study the liver targeting of neogambogic acid nanocapsules in mice. Methods ： The concentration of NGA in the heart, liver , spleen, lung, kidney, and blood were determined by HPLC. The distribution of NGA in mice was studied. And the targeting properly of NGA was evaluated. Results： The result showed that the test group was evidently different from the control group, which could evidently increase the distribution of NGA in liver. Conclusion： The NGA-NC has good liver targeting properly. |
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| Keywords: | neogambogic acid nanocapsules HPLC |
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