Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits |
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Authors: | P T Annamala K T Augusti |
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Institution: | (1) Department of Biochemistry, University of Kerala, Trivandrum, (India) |
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Abstract: | Summary Treatment of alloxan diabetic rabbits with glibenclamide, the most potent of the sulfonylureas, for a period of 2 months, significantly ameliorated the diabetic condition. It produced a decrease in serum and liver lipids, amino acids, serum urea, blood sugar and urine sugar; increase in body weight, serum and liver proteins, liver glycogen, glucose tolerance and serum and liver acid labile phosphates. The possible mechanism of action of this hypoglycemic agent is discussed. |
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