封闭群东方田鼠的病理生物学特征观察

在野生动物进行实验动物化过程中 ,制定微生物控制的标准 ,可以采用两种方法 :(一 )从野生动物的各种器官组织 ,对各类病原体进行逐一分离 ,制定微生物控制的标准 ;(二 )先对野生动物进行病理学检查 ,全面了解在正常饲养繁殖条件下 ,动物各器官以及各种生理状态下它们的病理变化 ,根据病理变化的特点 ,筛选病原体。采用第一种方法 ,较盲目 ,费时。用第二种方法 ,一方面可以了解动物的病理生物学特点 ,积累基本的生物学数据 ;另一方面 ,可以根据病变的程度与特点 ,估计和预测可能的病原体的种类 ,达到筛选病原体的目的。通过对封闭繁殖的东方…

An Investigation of Bio-pathologic Changes in Closed Breeding Microtus fortis

The bio pathological changes in the closed breeding Microtus fortis (as a laboratory animal) were observed. Forty six cases of Microtus fortis were divided into 3 different age groups, and investigated by the pathological technique combined with the electron microscopey. Results showed pathologic changes of closed breeding Microfus fortis were located mainly in liver and lung with close relation to aging. Eight types of pathological changes were found. There were breast carcinoma and cryptorechism in indivignal cases. The electron microscopic characteristics of the breast carcinoma were different from that of KM mouse. Therefore, for establishing a standardized laboratory animal, it is necessary to do pathological monitoring for Micritus fortis as a routine, and then in term of the results of which the germs may be screened.