The Preparation of Some Novel Indazole Derivatives by Using Chalcones

1 Introduction Indazole and its derivatives have little biological significance and have not been found in natural products due to the difficulty for living organisms to construct an N-N bond. Indazole derivatives exhibit variety of pharmacological properties such as anti-inflammatory, antidepressant, antitumor, antiarthritic and analgesic activities~(1]). Different synthetic pathways generate these compounds. For instance, ring closure of pyrazole moiety, addition of hydrazine derivatives t…

The Preparation of Some Novel Indazole Derivatives by Using Chalcones

Indazole and its derivatives have little biological significance and have not been found in natural products due to the difficulty for living organisms to construct an N - N bond. Indazole derivatives exhibit variety of pharmacological properties such as anti-inflammatory, antidepressant, antitumor, antiarthritic and analgesic activities. Different synthetic pathways generate these compounds. For instance, ring closure of pyrazole moiety, addition of hydrazine derivatives to carbonyl compounds and cycloaddition reaction. Herein, we report the synthesis of some new indazole derivatives by using chalcones as starting materials.