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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk |
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| Authors: | Broderick Peter Chubb Daniel Johnson David C Weinhold Niels Försti Asta Lloyd Amy Olver Bianca Ma Yussanne P Dobbins Sara E Walker Brian A Davies Faith E Gregory Walter A Child J Anthony Ross Fiona M Jackson Graham H Neben Kai Jauch Anna Hoffmann Per Mühleisen Thomas W Nöthen Markus M Moebus Susanne Tomlinson Ian P Goldschmidt Hartmut Hemminki Kari Morgan Gareth J Houlston Richard S |
| Institution: | Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK. |
| Abstract: | To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights. |
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