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Three-dimensional structure of calmodulin |
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| Authors: | Y S Babu J S Sack T J Greenhough C E Bugg A R Means W J Cook |
| Abstract: | The three-dimensional structure of calmodulin has been determined crystallographically at 3.0 A resolution. The molecule consists of two globular lobes connected by a long exposed alpha-helix. Each lobe binds two calcium ions through helix-loop-helix domains similar to those of other calcium-binding proteins. The long helix between the lobes may be involved in interactions of calmodulin with drugs and various proteins. |
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