| 生物酶促反应合成(S)-苯基-2-丙醇 |
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| 引用本文： | 李焰.生物酶促反应合成(S)-苯基-2-丙醇[J].湖北大学学报(自然科学版),1999(1). |
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| 作者姓名： | 李焰 |
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| 作者单位： | 湖北大学化学与材料科学学院!湖北武汉，430062(李焰，石从云，陈祖兴，邱波)，湖北大学生命科学学院!湖北武汉，430062(马立新) |
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| 基金项目： | 湖北省自然科学基金，湖北省教委科学基金 |
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| 摘 要： | （S）-苯砜-2-丙醇不仅具有抗胆甾脂的活性，而且还是一个非常有用的手性合成子．用自制的溴代丙酮与苯亚磺酸钠反应合成苯基丙酮砜，然后在面包酵母的作用下还原生成（S）-苯砜-2-丙醇．并对于干酵母及酵母培养液两反应方法进行了研究.它们具有操作简便、光学产率高等优点，其化学产率大于80％，光学产率达到95％．
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| 关 键 词： | 生物酶还原反应 （S）-苯基砜-2-丙醇 合成 |
The Preparation of (S)-Phenylsulfonyl-2-Propanol by Enzyme Catalysis Reaction |
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| Li Yan, Shi Congyun, Chen Zuziong, Qiu Bo, Ma Lixin.The Preparation of (S)-Phenylsulfonyl-2-Propanol by Enzyme Catalysis Reaction[J].Journal of Hubei University(Natural Science Edition),1999(1). |
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| Authors: | Li Yan Shi Congyun Chen Zuziong Qiu Bo Ma Lixin |
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| Abstract: | (S ) - phenylsulfonyl - 2 - propanol exhibited a anticholesteremic activity , and is an important available chiral synthon. 1 - phenylsulfonyl - 2 - propanone have been synthesized from sodium benzenesulfinate and bromoacetone which was prepared by the bromization of acetone, and reduced to (S ) - 1 - phenylsulfonyl- 2 - propanol under the action of baker's yeast. Also have studied two methods of bioenzyme catalysis reactions by using dry baker's yeast and freshly inoculum of baker's yeast. They are operated simply and gave high optical yields. The chemical yield is 80%, the enantiomeric excessis of (S ) - 1 - phenylsulformyl - 2 - propanol is over 95 %. |
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| Keywords: | Bioenzyme Catalysis reachon (S ) -1 - phenylsulfonyl - 2 - propanol Synthesis |
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