| 摘 要： | n and human diseases.gene-environment interaction;human diseases;environmental genome project国家自然科学基金(30671740,30271113)项目0复旦学报(医学版)Fudan University Journal of Medical Sciences147-150R363E05973E;E059_73冀芳;935-938低出生体重的遗传与环境交互作用研究进展林玲;张蕴晖;复旦大学公共卫生学院环境卫生学教研室,复旦大学公共卫生学院环境卫生学教研室 上海200032,上海200032低出生体重;;疾病负担;;遗传因素;;环境因素新生儿低出生体重是影响婴儿死亡和儿童发育的一个重要原因,已经成为儿童疾病负担的主要危险因素之一。低出生体重能导致围生期死亡率和各种疾病发病率增高,并影响将来的生长过程以及神经系统发育,还可导致成年后心血管疾病发生的危险性增加。因而,研究新生儿低出生体重的危险因素,对于预防低出生体重的发生、降低儿童疾病负担和提高我国人口素质有着非常重要的现实意义。本文就引起低出生体重的遗传、环境因素做一综述,以期全面地了解低出生体重的成因,为将来的防治工作提供依据和理论基础。Research progress on genetic and environmental interaction of low birth weightLIN Ling,ZHANG Yun-hui(Department of Environmental Health,School of Public Health,Fudan University,Shanghai,200032 China)Low birth weight is an important reason of newborn infants' death and children development and also one of the risk factors of children disease burden.Low birth weight can cause an increase in prenatal mortality and disease incidence,influence the process of growth and the development of nervous system,and cause an increase in the incidence of cardiovascular disease when grown up.Accordingly,it is very important to study the risk factors of low birth weight to prevent the occurrence,cut down children's disease burden and elevate the population disposition.This review summarizes the genetic and environmental factors of low birth weight so as to understand the reasons and provide the base and rationale of prevention.low birth weight;disease burden;genetic factor;environmental factor国家自然科学青年基金项目(30500397)0复旦学报(医学版)Fudan University Journal of Medical Sciences151-154R179E05572E;E055_72林玲;939-942复旦学报(医学版)2007年第34卷总目次FUDAN UNIVERSITY JOURNAL OF MEDICAL SCIENCES Vol.34,2007 General Contents0复旦学报(医学版)Fudan University Journal of Medical Sciences155-166R-5E0546E;E054_6943-954《复旦学报(医学版)》投稿须知0复旦学报(医学版)Fudan University Journal of Medical Sciences2 167R-5E0546E;E054_6790 955罗氏电化学发光检测系统检测泌乳素的方法学评价及参考范围建立黄志基;黄铭颖;岑屹;林瑶;吕元;复旦大学医学院附属华山医院检验医学中心,复旦大学医学院附属华山医院检验医学中心,复旦大学医学院附属华山医院检验医学中心,复旦大学医学院附属华山医院检验医学中心,复旦大学医学院附属华山医院检验医学中心 上海200040,上海200040,上海200040,上海200040,上海200040泌乳素;;参考区间;;方法学评价目的按美国病理家协会(CAP)对实验室的要求,对罗氏电化学发光系统检测泌乳素(PRL)的方法进行评估和建立本实验室的参考区间。方法取中、低值患者混合血清,分别进行批内20次和连续20 d检测,统计分析批内变异系数(CV)和日间CV;用不同浓度低值血清连续检测10 d,统计分析检测功能灵敏度;将高、低值血清按一定比例混合,检测PRL,回归分析确定测量范围;将中值血清按一定比例稀释后检测PRL,分析稀释后样本和原始样本结果的符合程度,得出临床可报告范围(CRR);取292名健康人群样本检测PRL,统计分析建立参考范围。结果中、低值批内CV分别为0.95%、1.16%,日间CV分别为2.39%、3.14%;功能灵敏度为0.065μg/L;分析测量范围(AMR)为0.105~452.88μg/L;CRR为0.065~4 528.80μg/L;本实验室的参考区间男性为3.86~22.80μg/L,女性为4.61~30.74μg/L。结论本系统检测性能符合CAP要求,参考区间上限略高于厂家提供的参数,说明厂家提供的参考区间不可直接引用。Evaluation of the method for prolactin with Roche electro chemiluminescence system and establishment of the reference rangeHUANG Zhiji,HUANG Mingying,CEN Yi,LIN Yao,L Yuan.(Center of Laboratory Medicine,Huashan Hospital,Fudan University Medical College,Shanghai 200040,China)Objective To evaluate the method for determination of prolactin(PRL) with Roche electro chemiluminescence(ECL) system and establish the reference range in our laboratory. MethodsThe within-run and between-day coefficient of variation(CV) was performed with middle and low lever mixed serum.The functional sensitivity
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