| 双氯芬酸钠-β-环糊精包合物的组成及性质研究 |
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| 引用本文： | 李国茹. 双氯芬酸钠-β-环糊精包合物的组成及性质研究[J]. 河南科学, 2001, 19(3): 243-245 |
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| 作者姓名： | 李国茹 |
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| 作者单位： | 河南中医学院中药系, |
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| 摘 要： | 用共沉淀法制备了双氯芬酸钠 β 环糊精包合物 ;经摩尔率比法测定 ,含量分析及物理常数测定确证 ,该包合物有 1∶1和 2∶1两种组成 ;溶解度测定结果表明 ,两种类型的包合物的溶解度比原药有所提高 ;胃刺激性试验表明 ,两种组成的包合物的刺激性都明显减小 ,2∶1型的刺激性最小。
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| 关 键 词： | 双氯芬酸钠 β环糊精 包合物 |
| 文章编号： | 1004-3918(2001)03-0243-03 |
| 修稿时间： | 2001-05-09 |
Study on the composition and properties of inclusion compound diclofenac sodium with β-cyclodextrin |
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| LI Guo ru. Study on the composition and properties of inclusion compound diclofenac sodium with β-cyclodextrin[J]. Henan Science, 2001, 19(3): 243-245 |
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| Authors: | LI Guo ru |
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| Abstract: | The inclusion compounds, diclofenac sodium(DS) with β cyclodextrin (β CD) were prepared by con precipitate method. Determining physical constant and quantitative analysis showed that the molecular ratio of β CD to DS in the inclusion compounds was 1∶1 and 2∶1, respectively. The solubility of inclusive state DS was larger than that of the drug DS, and itsirritation to stomach was smaller than that of DS,and this irritation of 2∶1 inclusion compound was the smallest. |
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| Keywords: | diclofenac sodium β cyclodextrin inclusion compound |
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