虎杖对大鼠酒精性脂肪肝的干预作用及其机制研究

目的探讨中药虎杖对酒精性脂肪肝模型大鼠的防治作用。方法以白酒灌胃的方法建立酒精性脂肪肝大鼠模型。大鼠随机分为空白对照组、模型组、凯西莱(阳性对照)组、虎杖大、中、小剂量组。以肝指数,内脏脂肪指数,血清NO、ALT、AST、CHOL、TG、LDL、HDL,肝组织匀浆SOD、MDA和肝组织脂肪变性程度等为主要观察指标。结果与模型组比较,虎杖大剂量组肝小叶中仅有少量细胞脂肪变性,肝细胞内脂滴颗粒较小,肝指数、内脏脂肪指数、AST、ALT、MAD和NO降低、SOD升高;虎杖中剂量组除AST外也降低;虎杖小剂量组肝指数降低;虎杖大、中、小剂量组TG、CHOL、HDL、LDL均显著降低(P0.01,P0.05)。结论虎杖对酒精性脂肪肝有明显的防治作用。

INTERVENTION EFFECT AND MECHANISM OF POLYGONUM CUSPIDATUM ON ALCOHOLIC FATTY LIVER IN RATS

Objective: To explore the preventive and therapeutic effects of Polygonum cuspidatum on alcoholic fatty liver in rats. Methods: The model of alcoholic fatty liver rats were established by feeding alcohol. Rats were divided into P. cuspidatum treatment groups including (high, medium-and low-dose group), corresponding control groups(blank group and model group). Liver index, visceral fat index, NO, ALT, AST, CHOL, TG, LDL, HDL level in serum, SOD, MDA in liver tissue and steatosis of liver tissue were determined. Results: Compared with the model group, there were only a small amount of steatosis cell and small particles of lipid droplets in liver cells in P. cuspidatum high-dose group, liver index, visceral fat index, AST, ALT, MAD, NO of high-dose group were lower, but SOD was higher than that in model group; AST was lower in P. cuspidatum medium-dose group than model group; liver index of P. cuspidatum low-dose group was lower than that in model group; TG, CHOL, HDL, LDL of P. cuspidatum groups was lower than model group all (P<0.01, P<0.05). Conclusion: P. cuspidatum had the effects of preventing and treating alcoholic fatty liver.