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Immunohistological investigations of N-Acetylserotonin in the rat cerebellum after parachlorophenylalanine treatment
Authors:G A Bubenik  G M Brown  L J Grota
Institution:(1) Neuroendocrinology Research Section, Clarke Institute of Psychiatry, 250 College Street, M5T 1R8 Toronto, Ontario, Canada;(2) Present address: Department of Psychiatry, University of Rochester, School of Medicine and Dentistry, 14642 Rochester, N.Y., USA
Abstract:Summary The amount of N-acetylserotonin (NAS) in the granule layer of the rat cerebellum was investigated using immunohistologic double antibody technique. After 5 days of treatment with parachlorophenylalanine (PCPA) an increase of NAS was observed. The possibility of a differential effect of PCPA on serotonin synthesis in the neurons and the nerve terminals is discussed.
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