Nickel-catalyzed alkene ipso-selective reductive hydroamination with nitroarenes |
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Authors: | Zhen Li Jiawang Wang Xi Lu Yao Fu |
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Affiliation: | Department of Applied Chemistry, University of Science and Technology of China, Hefei 230026, China |
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Abstract: | Aromatic amine synthesis via reductive coupling between alkenes and nitroarenes is attractive; however, it remains underdeveloped. Herein, we report a nickel-catalyzed alkene hydroamination with nitroarenes under mild reductive conditions. This reaction exhibited an ipso-selectivity and enabled repaid preparation of aromatic amines with primary and secondary alkyl groups. Many functional groups were well tolerated, providing an efficient approach for drug-like arylamine synthesis. |
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Keywords: | nickel alkene nitroarene reductive hydroamination C-N coupling |
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