Attenuation of diabetic retinopathy by the molecular chaperone-inducer amino acid analogue canavanine in streptozotocin-diabetic rats |
| |
| Authors: | K Mihály S Tóth L Szlávik A Tóth P Csermely |
| |
| Institution: | (1) Department of Medical Chemistry, Semmelweis University, P.O. Box 260, H-1444 Budapest 8 (Hungary), Fax +36 1 266 6550, e-mail: csermely@puskin.sote.hu, HU |
| |
| Abstract: | The effect of canavanine treatment on the electroretinograms of healthy and streptozotocin-diabetic rats was studied. The
characteristic amplitudes of the a-wave, W2 and W3 oscillatory potentials were markedly diminished in the 2-week streptozotocin-diabetic rats compared with those of the control
rats. In contrast, the amplitudes of all the responses of the canavanine-pretreated streptozotocin-diabetic rats were practically
indistinguishable from those of the control animals. Our results prompt further investigations for the use of amino acid analogues
and other inducers of molecular chaperones in easing the chronic consequences of diabetes such as retinopathy.
Received 3 June 1998; received after revision 14 August 1998; accepted 14 August 1998 |
| |
| Keywords: | , Molecular chaperone, heat shock protein, Hsp70, canavanine, retina, retinopathy, electroretinography, |
| 本文献已被 SpringerLink 等数据库收录！ |
|
