A Sultone Route to the Antileukemic 1 ,10-Seco-Eudesmanolides ( - )-Eriolanin and ( - )-Eriolangin |
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作者姓名: | J. Merten A. Hennig P. Metz |
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作者单位: | Institut fiir Organische Chemie, TU Dresden, Bergstr. 66, D - 01069 Dresden, Germany |
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摘 要: | The highly oxygenated 1,10-seco-eudesmanolides ( - )-eriolanin ( 1 ) and ( - )-eriolangin (2) isolated from the plant Eriophyllum lanatum (Asteraceae) inhibit the growth of the human KB tumor cell line in vitro and additionally display a significant antileukemie activity in vivo in mice (Scheme 1 ). Using novel methods for the synthetic elaboration of sultones, the first enantioseleetive total syntheses of 1 and 2 have been accomplished, which also established the hitherto unknown absolute configuration of these natural produets.
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关 键 词: | 多米骨效应 自然产物 硫磺杂环 磺内脂 萜类化合物 合成方法 |
文章编号: | 0427-7104(2005)05-0730-02 |
收稿时间: | 2005-08-05 |
修稿时间: | 2005-08-05 |
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