| A Sultone Route to the Antileukemic 1 ,10-Seco-Eudesmanolides （ - ）-Eriolanin and （ - ）-Eriolangin |
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| 作者姓名： | J. Merten A. Hennig P. Metz |
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| 作者单位： | Institut fiir Organische Chemie, TU Dresden, Bergstr. 66, D - 01069 Dresden, Germany |
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| 摘 要： | The highly oxygenated 1,10-seco-eudesmanolides （ - ）-eriolanin （ 1 ） and （ - ）-eriolangin （2） isolated from the plant Eriophyllum lanatum （Asteraceae） inhibit the growth of the human KB tumor cell line in vitro and additionally display a significant antileukemie activity in vivo in mice （Scheme 1 ）. Using novel methods for the synthetic elaboration of sultones, the first enantioseleetive total syntheses of 1 and 2 have been accomplished, which also established the hitherto unknown absolute configuration of these natural produets.
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| 关 键 词： | 多米骨效应 自然产物 硫磺杂环 磺内脂 萜类化合物 合成方法 |
| 文章编号： | 0427-7104（2005）05-0730-02 |
| 收稿时间： | 2005-08-05 |
| 修稿时间： | 2005-08-05 |
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