The cell cycle: a new entry in the field of Ca2+ signaling |
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Authors: | L. Santella E. Ercolano G. A. Nusco |
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Affiliation: | (1) Laboratory of Cell Signaling, Stazione Zoologica ‘Anton Dohrn’ Villa Comunale, 80121 Naples, Italy |
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Abstract: | Ca2+ signaling plays a crucial role in virtually all cellular processes, from the origin of new life at fertilization to the end of life when cells die. Both the influx of external Ca2+ through Ca2+-permeable channels and its release from intracellular stores are essential to the signaling function. Intracellular Ca2+ is influenced by mitogenic factors which control the entry and progression of the cell cycle; this is a strong indication for a role of Ca2+ in the control of the cycle, but surprisingly, the possibility of such a role has only been paid scant attention in the literature. Substantial progress has nevertheless been made in recent years in relating Ca2+ and the principal decoder of its information, calmodulin, to the modulation of various cycle steps. The aim of this review is to critically discuss the evidence for a role of Ca2+ in the cell cycle and to discuss Ca2+-dependent pathways regulating cell growth and differentiation. Received 2 March 2005; received after revision 9 May 2005; accepted 24 May 2005 |
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Keywords: | Calcium signaling mitosis meiosis cyclin-dependent kinase maturation-promoting factor InsP3 fertilization |
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