| 吐温80对99mTc-替曲膦脂溶性、血浆蛋白结合及生物分布的影响 |
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| 引用本文： | 陆洁,王学斌. 吐温80对99mTc-替曲膦脂溶性、血浆蛋白结合及生物分布的影响[J]. 北京师范大学学报(自然科学版), 2002, 38(3): 386-389. DOI: 10.3321/j.issn:0476-0301.2002.03.018 |
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| 作者姓名： | 陆洁 王学斌 |
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| 作者单位： | 北京师范大学化学系,北京,100875 |
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| 基金项目： | 北京市科委重点项目;953304300; |
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| 摘 要： | 通过向心肌灌注显像剂99mTc-替曲膦注射液中加入吐温80溶液得到99mTc-替曲膦+吐温80(w=0.1%)混合注射液. 对这2种注射液的脂水分配系数、血浆蛋白结合的测定以及小鼠体内的生物分布实验表明,吐温80的引入使配 合物99mTc-替曲膦的脂溶性、血浆蛋白结合及生物分布均发生了改变. 与未加 吐温80的99mTc-替曲膦注射液相比,混合注射液的生物性能得到明显改善,主要表现为肝摄取率的降低和心/肝摄取率比值的增加.
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| 关 键 词： | 吐温80 99mTc-替曲膦 心肌灌注显像剂 生 物分布 |
| 修稿时间： | 2001-11-30 |
EFFECT OF TWEEN80 ON THE LIPOPHILICITY, PLASMA BINDING AND BIODISTRIBUTION OF 99mTc-TETROFOSMIN |
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| Lu Jie Wang Xuebin. EFFECT OF TWEEN80 ON THE LIPOPHILICITY, PLASMA BINDING AND BIODISTRIBUTION OF 99mTc-TETROFOSMIN[J]. Journal of Beijing Normal University(Natural Science), 2002, 38(3): 386-389. DOI: 10.3321/j.issn:0476-0301.2002.03.018 |
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| Authors: | Lu Jie Wang Xuebin |
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| Abstract: | The mixed injection is prepared by adding Tween80 solution to the 99m Tc tetrofosmin injection. The lipophilicity, protein binding and in vivo distribution of the two injections are studied. The results indicate that the partition coefficient and plasma binding are changed for the addition of Tween80. Compared with 99m Tc tetrofosmin, the 99m Tc tetrofosmin+ Tween 80 ( w =0.1%) mixed injection has lower liver uptake and higher heart/liver ratio. |
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| Keywords: | Tween80 99m Tc tetrofosmin myocardial perfusion imaging agent biodistribution |
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