| NKC－1中草药合剂对T24－ras活化癌基因转化细胞的选择性杀伤及抗肿瘤作用的研究 |
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| 引用本文： | 陈雅文,陈雄伟,李青,杨其伟,孙丙刚,赵西林,陈德风.NKC－1中草药合剂对T24－ras活化癌基因转化细胞的选择性杀伤及抗肿瘤作用的研究[J].南开大学学报,1995(3). |
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| 作者姓名： | 陈雅文 陈雄伟 李青 杨其伟 孙丙刚 赵西林 陈德风 |
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| 作者单位： | 南开大学分子生物学研究所 |
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| 摘 要： | 根据我国传统中医药理论及现代分子生物学知识，设计并配制了具有抗肿瘤效应的复方中草药合剂ＮＫＣ－１．体外实验表明：ＮＫＣ－１能够选择性杀死ｒａｓ癌基因诱导的转化细胞，在较低浓度条件下对转化细胞的恶性行为有一定的抑制和逆转作用。急性毒性实验结果显示：当注射剂量为０．８ｍｌ／只昆明鼠时，仍无严重毒性。裸鼠体内实验表明：ＮＫＣ－１具有良好的抑制肿瘤效应。
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| 关 键 词： | 复方中草药 ras癌基因 细胞转化 裸鼠实验 |
STUDIES OF THE SELECTIVE KILLING OF NKC-1 ON TRANSFORMED CELLS INDUCED BY T24-RAS ACTIVATED ONCOGENE AND ITS ANTITUMOR EFFECT |
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| Chen Yawen, Chen Xiongwei, Li Qing,Yang Qiwei, Sun Binggang, Zhao Xiling, Chen Defeng.STUDIES OF THE SELECTIVE KILLING OF NKC-1 ON TRANSFORMED CELLS INDUCED BY T24-RAS ACTIVATED ONCOGENE AND ITS ANTITUMOR EFFECT[J].Acta Scientiarum Naturalium University Nankaiensis,1995(3). |
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| Authors: | Chen Yawen Chen Xiongwei Li Qing Yang Qiwei Sun Binggang Zhao Xiling Chen Defeng |
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| Abstract: | According to the theories of Chinese traditional medicine and the modern molecular biology, the mixed Chinese traditional herb NKC-1 was designed. The experiments in vitro show that the NKC-1 can kill the transformed cells induced by activited ras gene or repress the activited ras gene expression partly at lower concentration. The acute toxic experiments indicate that NKC-1 is not very toxic to the kunming mouse when the injected amount is 0. 8 ml per one. Also NKC-1 inhibits the forming of tumor or decreases the growth rate of cancer cells in nude mouse. |
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| Keywords: | mixed chinese traditional herb ras-oncogene transformed cell experiment of nude mouse |
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