| N-二异丙氧磷酰化壳寡糖的合成与表征 |
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| 引用本文： | 马力,李广华,李克让,李利民,刘蒲. N-二异丙氧磷酰化壳寡糖的合成与表征[J]. 郑州大学学报(理学版), 2011, 43(4) |
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| 作者姓名： | 马力 李广华 李克让 李利民 刘蒲 |
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| 作者单位： | 郑州大学化学系 河南郑州450001 |
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| 基金项目： | 国家自然科学基金资助项目,编号20872134 |
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| 摘 要： | 通过壳寡糖和二异丙基亚磷酸酯在一种温和条件下发生Atherton-Todd反应,成功制备出了一种新型的壳寡糖含磷衍生物N-二异丙氧磷酰化壳寡糖.探讨了水与无水乙醇的体积比、壳寡糖与三乙胺的摩尔比、壳寡糖与二异丙基亚磷酸酯的摩尔比以及反应时间等因素对产品含磷量的影响.最后,对最优条件下合成的产品进行IR、1H-NMR、13C-NMR以及31P-NMR的表征,证明二异丙氧磷酰基已经成功嫁接到了壳寡糖的氨基上.这种简单而有效的方法为N-磷酰化壳聚糖衍生物的制备提供了一条新的途径.
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| 关 键 词： | 壳寡糖 N-二异丙氧磷酰化壳寡糖 Atherton-Todd反应 表征 |
Synthesis and Characterization of Diisopropyl Phosphoryl Chitosan |
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| MA Li , LI Guang-hua , LI Ke-rang , LI Li-min , LIU Pu. Synthesis and Characterization of Diisopropyl Phosphoryl Chitosan[J]. Journal of Zhengzhou University(Natrual Science Edition), 2011, 43(4) |
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| Authors: | MA Li LI Guang-hua LI Ke-rang LI Li-min LIU Pu |
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| Affiliation: | MA Li,LI Guang-hua,LI Ke-rang,LI Li-min,LIU Pu(Department of Chemistry,Zhengzhou University,Zhengzhou 450001,China) |
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| Abstract: | A novel diisopropyl phosphoryl chitosan was successfully synthesized by Atherton-Todd reaction of chitosan with diisopropyl phosphite.The effects of reaction conditions including volume ratio of water to ethanol,molar ratio of chitosan to triethylamine,molar ratio of chitosan to diisopropyl phosphite,and reaction time at the room temperature on the phosphorus content were investigated.IR,1H-NMR,13C-NMR and 31P-NMR showed that diisopropyl phosphoryl group was grafted on the amino group of chitosan.The result... |
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| Keywords: | chitosan diisopropyl phosphoryl chitosan Atherton-Todd reaction characterization |
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