| 黄藤合剂的急性毒性和药效学研究 |
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| 引用本文： | 范念斯,杨军英,赵青青. 黄藤合剂的急性毒性和药效学研究[J]. 郑州大学学报(理学版), 2011, 0(3) |
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| 作者姓名： | 范念斯 杨军英 赵青青 |
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| 作者单位： | 河南师范大学生命科学学院省部共建细胞分化调控重点实验室; |
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| 基金项目： | 河南师范大学科研启动项目,编号0714;河南师范大学青年科学基金资助项目,编号525195 |
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| 摘 要： | 用热板法和扭体法研究黄藤合剂镇痛效果,测定毛细血管通透性和炎症组织PGE2含量以研究其抗炎活性及机理.小鼠灌胃给予黄藤合剂最大给药量76.8 g/kg后,7天内未见明显异常变化.黄藤合剂8mg/kg即能明显提高小鼠对热刺激的痛阈值,减少醋酸引起的扭体次数,降低毛细血管通透性,减少炎症组织PGE2的含量.16 g/kg,还能推迟疼痛反应出现的时间,延长潜伏期.黄藤合剂具有镇痛抗炎作用,最大给药量为76.8 g/kg,其作用机理可能与减少PGE2含量有关.
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| 关 键 词： | 黄藤合剂 镇痛 抗炎 |
Effects on Acute Toxicity,Analgesia and Anti-inflammatory of Huangteng Vinum in Mice |
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| FAN Nian-si,YANG Jun-ying,ZHAO Qing-qing. Effects on Acute Toxicity,Analgesia and Anti-inflammatory of Huangteng Vinum in Mice[J]. Journal of Zhengzhou University(Natrual Science Edition), 2011, 0(3) |
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| Authors: | FAN Nian-si YANG Jun-ying ZHAO Qing-qing |
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| Affiliation: | FAN Nian-si,YANG Jun-ying,ZHAO Qing-qing(Key Laboratory for Cell Differentiation Regulation,College of Life Sciences,Henan Normal University,Xinxiang 453007,China) |
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| Abstract: | Pain threshold and reaction were used to detect analgesic effect;blood capillary permeability and the content of PGE2 in inflammatory tissue were used to study anti-inflammatory effect.The maximum dose of administratior without toxicity was 76.8 g/kg,100 folds greater than that of adult of 60 kg body weight.Huangteng Vinum could obviously relieved the pain reaction induced by thermal stimulus as well as HAc in mice.It also could inhibit the swelling of foot and reduce the content of PGE2 induced by carragee... |
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| Keywords: | Huangteng Vinum analgesic anti-inflammatory |
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