Zur Spezifität des durch Bradykinin,Kallidin und Met-Kallidin ausgelösten Blutdruckreflexes an der Katze

Summary Synthetic kinins (bradykinin, kallidin and met-kallidin) administered via the femoral artery in the isolated hindlimb of the cat elicits vasoconstriction, a reflex on the systemic blood pressure, a stimulation of respiration, and contraction of nictitating membrane. Acetylcholine elicits these reflex reactions in the body too. Atropine blocks this reflex, but not the reactions of kinins. Phenylbutazone administered via the femoral artery blocks the reflex reactions of acetylcholine and kinins as well as the vasoconstriction of histamine and the kinins in the isolated hindlimb. Phenylbutazone elicits by itself a reflex reaction. Of all the synthetic substances, the kinins are the most specific drugs inducing reflex reactions.