Calcium accelerates cholesterol phase transitions in analog bile |
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| Authors: | M M Berenson J R Cardinal |
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| Institution: | (1) University of Utah School of Medicine and College of Pharmacy, 84132 Salt Lake City, Utah, USA |
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| Abstract: | Summary Analog bile supersaturated with cholesterol was constituted, filtered and divided into equal portions containing no calcium or calcium, 2.5–15 mM. Aliquots were removed over the next 48 h and filtrates analyzed for cholesterol, bile acid and lecithin. Calcium accelerated cholesterol loss from solution in a dose-related fashion. |
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| Keywords: | Calcium cholesterol supersaturation lithogenicity |
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