Endogenous inhibitor of ecdysone synthesis in crabs |
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| Authors: | Y Naya K Kishida M Sugiyama M Murata W Miki M Ohnishi K Nakanishi |
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| Affiliation: | Suntory Institute for Bioorganic Research, Osaka, Japan. |
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| Abstract: | Attempts to isolate the molt-inhibiting hormone (MIH) of crustaceans from crab eyestalks (ES) resulted in the characterization of xanthurenic acid as an inhibitor of ecdysone biosynthesis in the cultured Y-organ-complex (YOC) homogenate. It was also found that 3-hydroxy-L-kynurenine present in the ES is transformed into xanthurenic acid in the YOC and body fluid. Its mode of inhibitory action in ecdysone biosynthesis is probably inactivation of cytochrome P-450. |
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